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Ibrahim A.Albahlo1

College of Medicine, Jouf University, KSA

Title: Vitamin D and Pregnancy Complications Dilemma

Biography

Biography: Ibrahim A.Albahlo1

Abstract

Background: Vitamin D deficiency during pregnancy has been associated with some adverse neonatal outcomes as well as an increased risk of late pregnancy complications that include preeclampsia, gestational diabetes mellitus and increased risk of preterm labour.

Aim of work: to assess the corellation of pregnants serum Vit D level and different pregnancy complications regarding both mother and fetus and assess whether feto-maternal morbidities is associated with hypovitaminosis D or not.

Patients and Methods: 322 participants who meeted the inclusion citerias were classified into 2 groups. The first one was 110 pregnants with normal pregnancy regarding both fetal and maternal conditions were selected as control group.The second one was 212 pregnants suffering from pregnancy complications and were further subdevided into,58 cases with severe preeclamptic toxaemia associated with intrauterine growth restriction, 82 case with GDM, 26 cases of abortion, 16 cases undisturbed ectopic pregnancy,14 case with premature rupture of membranres=PROM and 16 cases with inevitable preterm labour. Serum recovered from peripheral blood samples by centrifugation was aliquot stored till used at -80 oC. Specific quantitative ELISA immunoassay kits from Sunlong Biotech Co. Ltd. were used to measure 25-OH-VitD (in ng/mL) and 1,25-DiOH-VitD (in pg/mL) (cat# SL2762Hu and SL2845Hu, Hangzhou, Zhejiang, China). The direct DiOH-VitD/OH-VitD ratio was calculated for each patient.

Results: .25 -OH -Vit D showed significant differences only between control and GDM groups while there were no significant differences among control and other groups. On the other hand,1,25-DiOH-VitD assay showed a very marked significant reductions in comparing control versus all of 6 complicated groups. Very similar to 1,25-DiOH-VitD pattern, DiOH-VitD/OH-VitD ratio showed nonsignificant difference among the complicated groups. However, there were very marked significant reductions comparing control vs. all of the 6 complicated groups

Conclusions: There is a strong association of vit D status and certain pregnancy complications.1,25 Di-OH-Vit D assay seems to be more reliable than 25-OH-Vit D and could be used as a suitable biomarker in assessment of vit D status in pregnancy. Vit D supplementation during pregnancy may assist in reducing related complications.

Keywords: Vitamin D, Pregnancy Outcomes, Pregnancy Complications